17 days old

Translational Omics Laboratory Lead

Pfizer
Cambridge, MA 02139
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**ROLE SUMMARY**



Global Bioanalytical Laboratory lead is a leadership role within the global biomarker discipline responsible for leading and effectively managing a global multi-disciplinary laboratory based across multiple locations within the DSRD biomarker organization. Key accountabilities of this position include development and implementation of biomarker strategies and experimental tactics to support investigative, exploratory, and regulated nonclinical studies, and executing human translatability questions and issues. The global bioanalytical lead is responsible for scouting, developing, and managing industry leading bioanalytical platforms and technologies to execute biomarker questions and generating decision-making quantifiable biomarker data. The lead is responsible for developing experimental options, alternative approaches, effective partnerships with partner-line bioanalytical groups within medicine and biomedicine design, RU and clinical groups. Data mining approaches and visualization mechanisms of large data by effective partnering with DSRD data operations and strategy team is also within the scope and an important responsibility of the lead. The lead is also responsible to work closely with clinical pathology discipline, biomarker discovery group and clinical and translational biomarker lead to effectively resource the DSRD strategy on translational biomarker initiatives including external consortia work. The lead works across the laboratory groups to connect, align and eliminate any silos to work as a global unit; serves as a mentor to laboratory colleagues to provide opportunities beyond the laboratory work and aggressively develop critical talent.



**ROLE RESPONSIBILITIES**



+ Performs all regulatory responsibilities in compliance with applicable regulatory standards.

+ Responsible for the efficient and effective development and execution of biomarker strategies including prioritizing projects with DSRD Global Biomarker discipline leadership.

+ Contribute to and ensure implementation of biomarker strategies in relation to project milestones, including hypothesis-driven novel biomarker identification, technical validation and biologic qualification applicable to preclinical models and evaluation of human translatability.

+ Accountable for managing, directing, supervising and leading the DSRD Global Bioanalytical laboratory in identification of the most appropriate existing or novel biomarker(s) based on independent research, scientific literature review and analytical thinking; for purposes of monitoring findings in investigative, exploratory, discovery and regulated studies. The platforms employed in this lab will include ELISA based multiplexing technologies, high-throughput immunoassays, cytometrybased assays, and RNA-based platforms (mRNA and miRNA).

+ Partners across research lines and within other biomarker lab groups (example, LC/MS group) to ensure effective clinical translation of biomarker assays when appropriate. Provision bioanalytical expertise to prioritized projects (e.g. by assigning representation on disease area biomarker teams). Aggressively develop colleagues and provide growth opportunities by actively scoping stretch assignments within and outside biomarker groups.

+ Contributes to the development of biomarker "Best Practices" and templates and implement effective and efficient platforms (e.g. high-throughput) for biomarker analysis using a wide range of assay methodologies, instrumentation and technical problem solving skills. Stay current and industry leading by effective partnering with Medicine and Biomedicine design bioanalytical groups and developing innovative relationships to drive DSRD deliverables.

+ Actively engage and partner with DSRD Data strategy and operations group to develop biomarker specific tools for data mining, analysis and visualization tools for decision making and information generation.

+ Participates in strategic meetings requiring decisions on relevant biomarkers to address safety findings; independently analyze and interpret data to design follow-up biomarker studies if needed; and effectively communicate biomarker data to biomarker teams and larger audiences as part of a collaborative multidisciplinary group.

+ This position also offers the opportunity to lead and actively participate in the drug discovery and development process as non-clinical safety representative to project teams (DSTL) and clinical biomarker lead





**BASIC QUALIFICATIONS**



Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.



+ MS or equivalent in biology/biochemistry, toxicology, or related field with >15 years related experience; DESIRABLE: PhD with >10 years relevant experience.





**PREFERRED QUALIFICATIONS**



+ Effective bioanalytical lab leader with demonstrated expertise in identification, validation, and qualification of new and existing biomarkers to assess translation to human and/or utility in nonclinical species.

+ Experience working on collaborative research projects within a matrix organization. Deep expertise and working knowledge in the application of multiplexing immunoassays, FACS, and basic molecular biology tools to biomarker development within a pharmaceutical or contract research organization. Current understanding of industry landscape in new technologies such as O-link, aptamer-based technologies, Quanterix and their application to address biomarker questions is important component of this role.

+ Basic understanding of good laboratory practice (GLP) principles, general understanding of chromatography and LC-MS applications and demonstrated ability to work across functional lines and geographical locations. Requires a strong understanding of assay and platform validation principles, and ability to transfer/cross-validate biomarker assays with internal and external partners. Previous exposure to laboratory automation and data management systems.

+ Excellent oral and written communication skills; and the ability to multitask across a diverse portfolio of projects and build strong relationships with stakeholders across R&D.

+ Supervisory experience is highly preferred





**Other Job Details:**



Last Date to Apply for Job: June 15th, 2021



Additional Location Information: Cambridge, MA; Groton, CT



\#LI-PFE



**Sunshine Act**



Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.



**EEO & Employment Eligibility**



Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.



Research and Development



\#LI-PFE
Posted: 2021-05-28 Expires: 2021-06-28
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Translational Omics Laboratory Lead

Pfizer
Cambridge, MA 02139

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