15 days old

Senior Scientist, Tumor Immune Evasion

Pfizer
La Jolla, CA 92037
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**ROLE SUMMARY**

Pfizer Cancer Immunology Discovery (CID) is within the Oncology division of Pfizer Worldwide Research & Development in La Jolla, CA. CID is dedicated to developing new protein therapeutics to improve human life by redirecting the immune system against cancer. CID researchers apply the latest scientific knowledge and novel approaches to discover truly innovative Immuno-Oncology therapeutics. We are seeking to hire a Senior Scientist for the Cytokine Biology CID group.



**ROLE RESPONSIBILITIES**



+ Design and execution of mechanism of action (MOA) studies in tumor immunogenicity and immune evasion biology; inclusive of but not limited to neoantigen generation, epigenetic disruption of tumor defense mechanisms, immunogenic cell death/don't eat me signals, senescence and role of innate immune cells in tumor recognition.

+ Discover and develop new therapeutic modalities for cancer immunotherapy focusing on tumor intrinsic targets and mechanisms.

+ Collaborate with tumor cell biology, medicinal chemistry, computational biology group and clinical development group to pursue the most promising drug candidates through clinical trials.

+ Participate in collaboration on novel oncology targets and therapeutics with internal and external collaborators

+ Communication of research results to team and company.



**BASIC QUALIFICATIONS**



+ Ph.D. with 1+ years of relevant scientific experience in the fields of cancer cell biology, molecular oncology, immunology and/or genetics

+ Ability to independently design, plan and execute and interpret experiments

+ Ability to manage an independent research program with minimal supervision

+ Experience with various syngeneic murine tumor and/or xenograft human tumor models

+ Expertise in standard cancer cell biology and immunologic techniques

+ Excellent organization and planning skills, the ability to work in a fast-paced environment independently or as part of a team, good verbal and written communication, and strong motivation with a dedicated work ethic



**PREFERRED QUALIFICATIONS**



+ Strong track record in target identification/validation and screening approaches using small-molecule inhibitors and/or genetic manipulation (shRNA, CRISPR)

+ Perform cell-based assays across various technology platforms to assess target modulation and measure downstream signaling pathways- qRT-PCR, ChIP-seq, FACS, immunofluorescence, western blotting, ELISA, high content screening, etc.

+ Technical expertise with immune cell-based functional assays (e.g. activation, differentiation, proliferation, and suppression assays by using, T-cells, monocyte/ macrophages, or dendritic cells)

+ Experience with human PBMC and mammalian cell culture



**PHYSICAL/MENTAL REQUIREMENTS**



+ Standing, sitting, bending, lifting, walking in a laboratory or vivarium setting

+ Use of Personal Protective Equipment (PPE) in a BSL-2 laboratory; additional PPE requirements when working in vivarium barrier suites

+ Standard business office conditions; sitting, standing as appropriate



**Other Job Details:**



+ Eligible for Relocation Package

+ Eligible for Employee Referral Bonus

+ \#LI-PFE



**Sunshine Act**

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.



**EEO & Employment Eligibility**

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.



Research and Development
Posted: 2020-05-11 Expires: 2020-06-11
Sponsored by:
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Senior Scientist, Tumor Immune Evasion

Pfizer
La Jolla, CA 92037

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