1+ months

Senior Scientist, Immunosuppression I

La Jolla, CA 92037
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**Role Summary**

Pfizer Cancer Immunology Discovery (CID) is within the Oncology division of Pfizer Worldwide Research & Development in La Jolla, CA. CID is dedicated to developing new protein therapeutics to improve human life by redirecting the immune system against cancer. CID researchers apply the latest scientific knowledge and novel approaches to discover truly innovative Immuno-Oncology therapeutics. We are seeking to hire multiple Senior Scientists for the CID Immunosuppression group.


+ Discovery and evaluation of novel mechanisms of tumor resistance to innate and adaptive immunity

+ Design and execution of cell based functional and biochemical assays to select candidate molecules for clinical development

+ Design and execution of drug mechanism of action studies using in vivo models and ex vivo methods, such as cell sorting, multi-color flow cytometry, immunohistochemistry/immunofluorescence, and primary cell culture and human 3D/organoid/explant assays.

+ Communication of research results to team and company

**Basic Qualifications**

+ Ph.D. with 1+ years of experience; or MS with 7+ years of experience, or BS/BA with 10+ years' experience

+ Experience in the fields of immunology, cell biology and/or genetics

+ Ability to independently design, plan and execute and interpret experiments

+ Ability to manage an independent research program with minimal supervision

+ Expertise in standard immunologic techniques

+ Expertise in qRT-PCR, ELISA, MSD, ELISPOT, Nano string and cytotoxic assays

+ Experience in CRISPR technology, lentiviral transduction, data mining (TCGA, single cell RNA sequencing, cBioportal)

+ Experience working with small molecules inhibitors and biologics for tumor immunotherapy

+ Immune phenotyping tumor associated immune cells from primary human tumor samples by flow cytometry and other high dimensional approaches including CyTOF

**Preferred Qualifications**

+ Technical expertise with immune cell-based functional assays (e.g. activation, differentiation, proliferation, and suppression assays by using monocyte/ macrophages, T-cells, or dendritic cells, tumor-stroma immune cell co-culture assays)

+ Expertise in 3D spheroid and other complex ex vivo assays that mimic human tumor microenvironment

+ Experience with human PBMC and mammalian cell culture

+ Excellent organization and planning skills, the ability to work in a fast-paced environment independently or as part of a team, good verbal and written communication, and strong motivation with a dedicated work ethic

**Physical or Mental Requirements**

+ Standing, sitting, bending, lifting, walking in a laboratory or vivarium setting.

+ Use of Personal Protective Equipment (PPE) in a BSL-2 laboratory; additional PPE requirements when working in vivarium barrier suites.

+ Standard business office conditions; sitting, standing as appropriate

+ Infrequent travel

**Other Job Details**

+ Eligible for Relocation Package

+ Eligible for Employee Referral Bonus

+ \#LI-PFE

**Sunshine Act**

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

**EEO & Employment Eligibility**

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development
Posted: 2020-02-18 Expires: 2020-04-23

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Senior Scientist, Immunosuppression I

La Jolla, CA 92037

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