1+ months

Senior Scientist, BMD Biotherapeutic Protein Purification

Cambridge, MA 02139
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Pfizer's BioMedicine Design (BMD) Biotherapeutic Expression and Purification group (BEP) is seeking an experienced protein purification scientist. Qualified candidate will play an essential role in a high-energy protein purification research laboratory. The purification group is responsible for non-GMP protein drug lead generation, supporting the various Pfizer research units and their pre-clinical therapeutic in-vitro and in-vivo needs. The candidate will be responsible for processing of mammalian- expressed recombinant protein modalities including, but not limited to, monoclonal antibodies through the use of state-of-the-art technologies and equipment. The candidate will contribute to the group wide deliverables and be required to work on several projects simultaneously presenting results and updates at group meetings.


+ Develop methods for production and protein purification for downstream biotherapeutic production activities, and e nsure timely delivery of highly-purified biotherapeutic candidates to discovery project teams

+ Assess quality of biotherapeutics rigorously and review all analytical documentation prior to protein release

+ Design/optimization of experiments in support of the development of scalable protein purification processes as well as providing technical support across the therapeutic product development cycle

+ Conduct testing of new process formulas, technologies and products, including but not limited to: new product scale-up, process optimization, limited characterization of protein products, impurities, purification, technology transfer, process validation activities and development of production procedures and product specifications

+ Drive technology innovation. Maintain knowledge of scientific trends industry processes through readings, conferences and seminars; review literature to advance manufacturing procedures and methods

+ Work closely with multidisciplinary teams including therapeutic discovery teams, research units, bioanalytical teams, transient expression and stable cell line development groups, engineering leads, and R&D project leaders

+ Occasional travel to Pfizer site at Andover, MA


+ A PhD with 0-3 years of relevant experience in Biochemistry, Biology, Biological Engineering or a related discipline along with a solid understanding of antibodies/therapeutic proteins production

+ Experience and strong background protein biochemistry, protein expression, and protein purification (using affinity and traditional chromatographic techniques) using AKTA and Agilent chromatography systems, including operating Unicorn and ChemStation software packages.

+ Demonstrated technical expertise in mid- and large-scale purification of antibodies/ therapeutic proteins

+ Strong understanding of analytical biochemistry and experience in protein analytical characterization, including mass spectrometric analysis of protein

+ Track record of strong problem solving and troubleshooting skills, organized, detail oriented, a bility to prioritize responsibilities, multi-task, and remain flexible with changing needs

+ Must be motivated and able to work under strict deadlines

+ Able to work effectively in cross functional teams to solve process development problems or implement improved procedures

+ Strong written and oral communication skills


+ Industry experience in antibodies/therapeutic protein expression and purification

+ Past experience on designs and implements new procedures for purification process improvements

+ Experience with DOE concepts and tools

+ Python and/or VB experience

+ Prior experience in therapeutic protein discover and biochemistry research

+ Mentorship experience

**Sunshine Act**

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

**EEO & Employment Eligibility**

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development
Posted: 2020-02-24 Expires: 2020-04-25
Sponsored by:
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Senior Scientist, BMD Biotherapeutic Protein Purification

Cambridge, MA 02139

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