1+ months

Senior Manager Translational Medicine

Hedgesville, WV 25427
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+ Independently design, conduct and coordinate clinical and translational research activities involved in the evaluation and development of drugs within the Pfizer Oncology and non-oncology portfolio, focusing on pharmacodynamic proof-of-mechanism/pharmacology, patient selection/stratification and clinical proof-of-concept (POC), and underlying disease biology of relevance to combination therapy and drug sensitivity or resistance.

+ Independently identify, evaluate and prioritize candidate predictive biomarkers and develop clinical companion diagnostic tests that will appropriately transition from early to late phase clinical development.

+ Work directly with a variety of external contract research organizations/vendors as well as academic collaborators and key opinion leaders to execute and expand clinical translational research efforts.

+ Work collaboratively within highly integrated, multi-functional program teams that includes scientists within Discovery Research, Research Precision Medicine, Computational Biology, Clinical Pharmacology and Development Operations groups, as well as Clinicians, Statisticians, and Asset Team Leads.

**Technical Competencies**

+ Clinical Project Expertise: demonstrated potential or ability to independently design, initiate and conduct clinical studies focusing on integrating and executing biomarker analyses that support clinical development objectives

+ Scientific Excellence: demonstrated deep understanding of pre-clinical and clinical disease biology, and the ability to apply that knowledge to drug development; demonstrated understanding of the complexities and recent developments in the relevant therapeutic/technical area, and the ability to apply such knowledge to drug development

+ Presentation and analytical skills: demonstrate strong ability to present clinical data, study plans and tactics clearly and accurately to relevant audiences in order to obtain decision

**Behavioral Competencies**

+ Networking and Alliance Building: Able to work across many interfaces: clinical-regulatory; clinical-marketing; clinical-project management; clinical-development operations (biometrics, monitoring resource, study reporting)

+ Developing Others: Will be responsible for helping to mentor less experienced Translational Medicine Scientist, and to foster continued learning within the therapeutic areas, including collection and application of lesions learned

+ Influencing: be able to manage and motivate investigators and contract research organizations

+ Innovation: Constantly challenge existing paradigms in clinical research and encourage breakthrough designs; work with clinical development operations on study design, data capture and retrieval, reporting

+ Courage with decisiveness to Act: Bias towards action to achieving goals

+ Conflict Management: Good at focused listening; can find common ground and get cooperation with minimum noise

**Qualifications** Education:

+ PhD, MD, MD/PhD, Pharm. D or equivalen t qualifications. Postgraduate training/certification /fellowship in a medical discipline or in drug development with focus on disease biology and biomarkers. Candidates should possess an advanced and current understanding of cancer biology, cancer genetics and immunology, and demonstrate scientific productivity (e.g. doctoral thesis, publications, research reports, etc.)

Prior Experience:

+ Had > 5 years industry experience demonstrating excellence in designing, executing and interpreting studies of cancer biomarkers in clinical trials, including biomarker development, validation and clinical application; familiarity with clinical trial design, logistics and regulatory issues; familiarity with the development and regulatory approval of oncology companion diagnostics.

+ Demonstrated ability to think strategically and creatively while contributing to multiple projects and to work well in collaborative, multi-disciplinary team setting; effective verbal and written communication skills


Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.

Posted: 2020-04-16 Expires: 2020-07-18
Sponsored by:
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Senior Manager Translational Medicine

Hedgesville, WV 25427

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