11 days old

Scientist, Membrane Protein Purification

La Jolla, CA 92037
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Pfizer's BioMedicine Design (BMD) Biotherapeutics Discovery Group in La Jolla, CA is responsible for discovering and developing biotherapeutic drug candidates. The group is responsible for identification and engineering of Biotherapeutic proteins, protein production, and protein analytics. The group is currently looking for a **Scientist** to support the Biotherapeutics portfolio of Pfizer. The candidate will be responsible for the purification of membrane protein antigens and tool therapeutic reagents to advance the pipeline. The ideal candidate will be able to work closely with a team and communicate effectively to meet schedules and deadlines.


+ Expression and Purification of membrane proteins (including GPCRs, ion channels, transporters) for use in antibody discovery and/or structural/biophysical studies

+ Perform protein purification and analytics for the production of biotherapeutics leads, protein reagents, immunogens, and panning reagents

+ Characterize purified proteins by various biochemical and biophysical assays

+ Design and modify purification protocols to meet reagent requirements and deliverables

+ Effectively communicate research progress through oral presentations and written documentation

**Qualifications Required:**

+ BS or MS in biochemistry, chemistry, or a related discipline with at least 5 (BS) or 3 (MS) years of related scientific experience

+ Experience in purification of proteins from insect and/or mammalian cell culture systems using chromatographic methods

+ Practical experience in insect and/or mammalian cell culture, and purification of membrane proteins is desired

+ Experience with AKTA FPLC systems and Unicorn software

+ Experience with protein analysis like SDS-PAGE, western blot, and analytical SEC

+ Experience in molecular cloning and expression construct design considered a plus

+ Experience in structural biology would be advantageous

**Sunshine Act**

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

**EEO & Employment Eligibility**

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development

Posted: 2021-06-02 Expires: 2021-07-05
Sponsored by:
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Scientist, Membrane Protein Purification

La Jolla, CA 92037

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