1+ months

Principal Scientist, Translational Omics

Groton, CT 06340
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Pfizer is excited to present a Principal Scientist, Translational Omics position within our Drug Safety organization.


Biomarker science is a transformative discipline to catalyze and accelerate discovery and development of new therapeutics for patients with unmet medical need. As a Translational Omics Scientist, you will be responsible for discovering biological data and insights from multi-omics experiments and large datasets. You will have the opportunity to test a hypothesis using state-of-the-art omics platforms to discover and validate small and large RNAs, proteins, metabolites, lipids etc as safety and/or disease monitoring biomarkers. You will also have the opportunity to apply computational skills for biomarker discovery, development and translation. As a lead biomarker scientist, you will participate and provide scientific and technical leadership to drug development team members. In your role at Pfizer, you will also guide the strategy and champion the execution of biomarker datasets, innovations in biomarker science, publications and external partnerships.


+ Use cutting edge methodology/technology to discover, develop, validate and translate novel mechanistic multiparametric biomarker panels to understand phenotypic safety and pharmacology.

+ Contribute to the development of knowledge infrastructure and growing the content and analytical tools necessary to support biological interpretation of integrated omics molecular data.

+ Leverage understanding of biological pathways and disease pathogenesis to create insights from the analysis of integrated omics data and knowledge

+ Leadworkstreams for curation, integration of external databases, and text mining/Natural Language Processing.

+ Work closely withscientists across different disciplines within Drug Safety Research and Development such as investigative toxicology, pathology etc as well as departments across Pfizer such as early clinical development to align both knowledge content acquisition and development as well as analysis with organizational needs.

+ Evaluate public and commercial databases for relevance and quality

+ Develop curation guidelines and training materialsfor representation of biologicalknowledge.

+ Drive Science and Technology innovation proposals


+ Ph.D. with up to 4 years of experience in biological sciences preferably with focus in molecular biology or other advanced degree with significant experience in systems, omics and molecular biology, systems pharmacology, translational medicine, biomarker science, machine learning, bioengineering, toxicology and disease biology

+ Experience working with high-throughput molecular data and delivering high value insights. Expert in signaling pathways

+ Expertise with mechanistic investigation of toxicity findings and fit for purpose biomarker development/evaluation, with a strong track record of peer-reviewed publications, scientific presentations (e.g. abstracts, posters, podium presentations) related to biological sciences

+ Experiencewith biomedicaldatabases and ontologies. Familiaritywith scripting languages(e.g., Python) and/or R/Bioconductor. Experiencewithcommonly used software for data visualization(e.g., Spotfire)andsystems biology/pathway analysis (e.g.,Cytoscape, GSEA)

+ Strong attention to detail, communication, and organization skills. Team playerwithsolidcollaboration skills. Thrives in a fast-paced, dynamic, and mission-driven atmosphere


+ Experience with text mining or natural language processingarea plus, but not required

**Sunshine Act**

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

**EEO & Employment Eligibility**

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Other Job Details:

+ Additional Location Information: Groton, CT; La Jolla, CA and Andover, MA.

+ Eligible for Relocation Package

+ Eligible for Employee Referral Bonus


N (Other) (United States of America)

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.
Posted: 2019-09-10 Expires: 2020-08-23
Sponsored by:
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Principal Scientist, Translational Omics

Groton, CT 06340

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