1+ months

Principal Scientist, Phage/Yeast Display, Antibody Discovery

La Jolla, CA 92037
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Pfizer's Biotherapeutic Discovery group in La Jolla is seeking an outstanding and highly motivated Principal Scientist to aid in our biologics discovery, engineering and technology development projects. They will be responsible for working closely with individuals in both protein engineering and biology to develop the next generation of biologics. They will have access to state-of-the-art antibody generation technologies and will be expected to continue our tradition of developing world class methods and technologies that enhance our therapeutic antibody discovery efforts.


+ Responsible for isolating and optimizing antibodies using Pfizer's proprietary synthetic antibody libraries.

+ Work within a multidisciplinary and cross-functional team to advance biologics through different stages of the development

+ Generate highly diverse libraries and set up selections to obtain the desired function

+ Comfortable working with automation methods using liquid handling equipment

+ Independently design experiments, analyze data and troubleshoot methods

+ Desire to understand underlying biology and mechanism of targets and biologics.

+ Present experimental design and results at internal meetings


+ PhD in Biological Science (Molecular Biology, Structural Biology, Protein Biochemistry, Cell Biology) or a related field (Chemical Engineering, Biomedical Engineering and Biological Engineering) with postdoctoral experience and 3+ years of experience in an industry setting

+ Experience with using molecular biology to build libraries or perform high throughput cloning

+ Experience with using phage or yeast display

+ Experience engineering proteins with desired properties

+ Technical expertise should include molecular biology, protein expression/purification and characterization.

+ Strong track record of scientific accomplishments demonstrated through publications in highly regarded journals and/or intellectual property generation.

+ Track record of demonstrating analytical skills, creativity and unique problem solving

+ Outstanding pro-active attitude, interpersonal, collaborative and oral communication skills

+ Strong motivation, passion and commitment to science and engineering novel entities

+ Ability and desire to work in an interdisciplinary scientific team and the desire to learn new techniques

+ Strong time management skills and ability to manage multiple projects in parallel

+ Ability to analyze and interpret work published in the field and apply it appropriately

+ The individual should be scientifically creative and driven by a willingness to embrace innovation within drug discovery and an eagerness to challenge and meet aggressive timelines


+ Previous experience with protein expression and purification methods

+ Previous experience with antibody engineering

+ Previous experience with high throughput screening methods

+ Experience with mammalian display

+ Understanding structure-function is a plus.

**Physical or Mental Requirements**

+ Ability to perform mathematical calculations and ability to perform complex data analysis tasks.

**Other Job Details:**

+ Eligible for Employee Referral Bonus: Yes

+ \#LI-PFE

**Sunshine Act**

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

**EEO & Employment Eligibility**

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development
Posted: 2020-04-16 Expires: 2020-06-18
Sponsored by:
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Principal Scientist, Phage/Yeast Display, Antibody Discovery

La Jolla, CA 92037

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