1+ months

Principal Scientist, Materials Science

Pfizer
Groton, CT 06340
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**ROLE SUMMARY**

The Principal Scientist - Materials Science position is a laboratory-based position with responsibility for investigating and understanding the solid state chemistry of Pfizer's drug molecules. Responsibilities include generating solid state chemistry data using state-of-the-art instrumentation and computer models, and interpreting the data to allow new medicines to be brought to the market. He/She serves on multidisciplinary project teams and is responsible for defining the final drug substance form (salt/polymorph/hydrate) of active pharmaceutical ingredients (API) and the preferred physical attributes (particle shape/particle size/surface energy) needed for optimum API and drug product performance. The position is based in Groton, CT (USA).



**ROLE RESPONSIBILITIES**



+ Conduct solid state physical and chemical characterization of small molecules of pharmaceutical relevance. This includes particle characterization (e.g., particle size, shape) and solid state characterization (e.g., spectroscopy, X-ray powder diffraction, thermal analysis).

+ Crystallize neutral molecules, salt and co-crystal forms of drug candidates (including hydrates, solvates and polymorphs) and evaluate these forms for acceptability as drug substances as it relates to chemical manufacturing and formulation into pharmaceutical products.

+ Apply state-of-the-art computational approaches to predict the properties and performance of crystalline and amorphous drug substance samples.

+ Oversee the work of external partners conducting laboratory studies, and provide tactical guidance and critical analysis of raw data.

+ Solve scientific problems using contemporary solid state experimental and computational techniques.

+ Participate on multidisciplinary project teams, and collaborate with colleagues to define and implement screening and characterization strategies according to project timelines.

+ Draft and review sections of regulatory submissions as well as delivering reports to support patenting Pfizer's intellectual property.

+ Provide materials science support for colleagues in other departments.

+ Lead the development of new scientific approaches and knowledge within the global Materials Science organization.



**QUALIFICATIONS**

A PhD in chemistry, engineering, materials science, or pharmaceutics (or equivalent subject) and 3-8 years of relevant experience. The candidate should have experience in small molecule crystallization and solid state characterization (such as x-ray powder diffraction, polarized light microscopy, differential scanning calorimetry, thermogravimetric analysis, NMR, etc). Experience with using contemporary computational approaches to predict the properties and performance of pharmaceutical materials is desired. Strong data analysis skills and knowledge of statistical concepts is expected. Understanding of the physical properties needed for drug substance manufacture and formulation into drug product is desired. A strong interest and motivation to learn new technologies and concepts is expected. Good organizational skills, the ability to work independently, and excellent oral and written communication skills are required.



**Sunshine Act**

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.



**EEO & Employment Eligibility**

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.



Additional Job Information:



+ Eligible for Relocation Package

+ Eligible for Employee Referral Bonus



N (Other) (United States of America)

Pfizer is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.
Posted: 2019-08-16 Expires: 2019-10-17

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Principal Scientist, Materials Science

Pfizer
Groton, CT 06340

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