1+ months

Principal Scientist

La Jolla, CA 92037
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Pfizer is seeking applications for a Principal Scientist with extensive mass spectrometry-based proteomics experience. Such a candidate will be a highly motivated and creative scientist with the desire to lead and implement innovative proteomic capabilities for our oncology pipeline. This person will align with our Chemical Biology group enabling impact across the small molecule oncology portfolio from early exploratory target identification through the drug discovery pipeline and into early clinical development.

The individual will join the development and implementation of innovative mass spectrometry platforms. Their work will enable quantitative chemical proteomics methodologies for a deeper understanding of our molecules and cellular targets. Relevant methodologies include but are not limited to the identification of novel oncology targets, small molecule target deconvolution, small molecule target occupancy studies using chemical probes, direct substrate identification and characterization, protein turnover studies, protein post-translation modification studies and small molecule-protein interactome analyses.


Spearhead efforts in identifying, developing, and implementing innovative quantitative protein mass spectrometry technologies for chemo-proteomics and general proteomics across the oncology portfolio.

Participate in all aspects of laboratory operations including proteomic technology evaluation, proteomic software evaluation, development of quantitative sample preparation methods and peptide separation methods, data analysis and interpretation.

Presenting and reporting data with follow up discussions for project teams including data impact and interpretation.

Complete and effectively manage multiple projects within timelines ensuring that all tasks and responsibilities are carried out according to high scientific and ethical standards.

Mentor and cross-train colleagues in protein mass spectrometry workflows.

Build collaborative and strategic partnerships with internal and external research teams (leading universities and research institutes) to apply proteomics for oncology discovery, impacting all oncology research focuses including: Systems Therapeutics, Tumor Intrinsic Biology, Immuno-oncology and Epigenetics.

Publications in peer-reviewed scientific journals and external/internal presentations are expected.


Ph.D. in biological sciences, chemical biology, analytical chemistry, or a related field.

4 + years of post-doctoral or equivalent experience with applied mass spectrometry based proteomics required. Industry experience and oncology training is preferred.

Experience and knowledge in the operation and maintenance of different types of mass spectrometers including Q Exactive Hybrid Quadrupole and Orbitrap Fusion Lumos Tribrid.

Extensive knowledge and application of complex sample preparation methodologies as applied to protein mass spectrometry workflows.

Ability to characterize protein post-translational modifications including phosphorylation, methylation, acetylation, PARylation and ubiquitination.

Expertise in implementing quantitative mass spectrometry-based strategies including isotopic labeling, isobaric tagging, SILAC, and label-free analysis (DIA, PRM/SRM) methods.

Applied knowledge with MS software analysis pipelines including IP2, Proteome Discoverer, MaxQuant and Skyline.

General understanding of chemical proteomics methodologies including affinity enrichment, target occupancy and Chem-Seq.

General understanding of target deconvolution methods including CETSA, DARTS, FUSION and chemical probes/proteomics.

Excellent verbal and written communication skills.


Relocation eligible

Eligible for employee referral bonus


**Sunshine Act**

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

**EEO & Employment Eligibility**

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development
Posted: 2020-04-27 Expires: 2020-07-02
Sponsored by:
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Principal Scientist

La Jolla, CA 92037

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