30 days old

Principal Scientist, ESB, Rare Diseases

Cambridge, MA 02139
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Pfizer is making significant investment in the creation of novel, first-in-class therapeutics, by combining internal discovery and validation of drug targets with external partnerships to produce clinical drug candidates for the Pfizer pipeline. This position is within a newly created Emerging Sciences Biology (ESB) group within Target Sciences (TS). Target Sciences has expertise in human genetics, functional genomics, automated analytic capabilities and data management, and target validation biology. Target Sciences works together with Pfizer's Centers for Therapeutic Innovation (CTI) within Pfizer broader External Science & Innovation group to deliver a broad and deep pipeline of drug candidates, based on emerging science in the academic world.

The primary responsibility of the newly created Emerging Science Biology team is to play a driving role in addressing the critical task, identified as a gap, of rejuvenating the WRD pipeline with innovative, differentiated First-In-Class/ Only-In-Class programs in the years to come. This will be addressed by generation of strong data packages from target hypotheses derived from academic outreach and initiatives incl. ITENs, from human genetics, functional genomics and data mining to enable the initiation of new CTI and RU projects.

This position requires deep expertise in human rare diseases, a proven track record in managing target discovery and validation projects in a drug discovery setting, capability to execute, strong leadership skills, and the ability to network effectively at both a senior and hand- on level with CTI and RU biologists and Partner line scientists as well as with external academic PIs.


Key Deliverable:

o Leads scientific activities and projects for the design and execution of target validation studies defining confidence-in-rationale for potential drug targets and the pathway to pursue them in partnership with TS, CTI, Research Units, and Partner Line colleagues and external academics. This will include oversight of experimental work and 30-50% of time with hands-on experimentation.

o Establish strong data sets enabling objective decision making on specific prospective targets. Target candidates are discovered primarily through the hypothesis generation engine of Target Sciences but could also come from other sources.

o Collaborate successfully within a dynamic and agile group within the broader External Science and Innovation departmental structure and key partners to produce target packages for first-in-class drug discovery programs.

o While the primary responsibility will be to execute target validation plans to drive portfolio entry, it is expected that the incumbent to this role has high scientific and ethical standards and will produce outstanding work that will result in publication in top journals.


o PhD and 4+ years' experience in molecular biology, genomics and/or pharmacology or a closely related discipline.

o 2-4 years' industrial experience using genomic, molecular, cellular, and/or biochemical technologies to drive drug discovery in a pharmaceutical / biotech setting is highly preferred.

o Deep knowledge and hands-on experience in DNA damage repair/response and human disease biology mechanism, with a strong preference for rare diseases.

o Strong track record of basic biology mechanistic research ideally demonstrated in the context of leading target discovery and validation projects and reflected in a strong record of achievement in peer-reviewed publications.

o Overseeing or experience from collaborations with CRO, external academic and biotech resources is a plus.

o Excellent leadership, collaboration, communication, and organizational skills, and ability and desire to work as part of a team dedicated to innovation.


**Sunshine Act**

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

**EEO & Employment Eligibility**

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development
Posted: 2020-03-02 Expires: 2020-04-02

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Principal Scientist, ESB, Rare Diseases

Cambridge, MA 02139

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