14 days old

Postdoctoral Research Fellow

Andover, MA 01810
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The individual will join a team of scientists and engineers focused on developing and optimizing cell lines and mammalian cell culture processes for biologics production. The successful candidate will be employing state-of-art systems biology approaches to identify factors (metabolic byproducts or host cell proteins) that negatively affect the growth and productivity of mammalian cell lines in cell culture processes, and more importantly, probe/understand the physiological mechanisms responsible for emergence of such factors in cell culture processes. The individual will harness the full potential of cell metabolism and cell signaling literature/knowledge to design and execute transformational experiments to metabolically engineer mammalian cell lines and/or develop cell culture process control strategies towards attaining desired metabolic phenotype linked with enhanced cell growth and productivity. The job function requires sound scientific judgment and innovation using advanced practices and procedures to achieve solutions.


+ Designs and conducts bioreactor and shake-flask experiments using mammalian cell lines to study relevant metabolic phenotypes. Perform omics analysis (transcriptomics, proteomics, metabolomics) to build testable hypotheses on cellular mechanisms governing the relevant metabolic phenotypes.

+ Employs state-of-art technologies to overexpress or knockout/knockdown gene targets in mammalian cell lines to evaluate associated metabolic phenotypes.

+ Drives the project and works under limited supervision with periodic review of achievement of results and experimental approaches employed. Manages own time to meet agreed targets. Develops plans for short-term work activities.

+ Ensures effective, high-quality, timely and appropriate documentation in electronic laboratory notebooks and internal technical reports; presents data/ strategy to scientists and management in appropriate internal and external venues (technical meetings, project team meetings, conferences) and publishes in peer-reviewed journals, as appropriate.

+ Contributes to safe, efficient, effective and harmonious lab environment through personal responsibility/ accountability - ensures appropriate cleanliness and status/ operability of shared or assigned lab space or equipment; strong lab citizen and collaborative team player; approaches the job with energy and enthusiasm.


+ PhD in Chemical/Biochemical engineering, Bioengineering, Molecular biology/genetics, Biochemistry, Chemical Biology or related discipline with 0-3 years postgraduate experience in life-science/biotechnology field.

+ Experience in aseptic cultivation of suspension and/or adherent mammalian cell lines.

+ Experience with molecular cloning techniques such as plasmid construction, preparation and analysis, RNA, cDNA and genomic DNA preparation, sequencing, CRISPR/CAS9 technology is highly desired.

+ Experience in performing molecular biology assays including but not limited FACS, western blots, qRT-PCR, etc

+ Should be self-motivated, organized, and capable of working independently and in a collaborative environment and should have demonstrated ability to drive projects by coming up with innovative solutions

+ Should possess strong oral and written communication skills. Should have strong attention to detail and has ability to execute detailed experimental plans, record procedures, analyze data, and present results. Has ability to work in a team environment.


+ Experience in analysis of data generated from one or more 'omics technologies including but not limited to transcriptomics, proteomics, metabolomics etc.

+ Good understanding of glucose/amino acid metabolism and cell signaling pathways including, but not limited to, AMPK, PI3K-AKT-mTOR, HIF1a pathways.

+ Experience in operating lab scale mammalian cell culture bioreactor systems and computerized process control equipment.

**Other Job Details:**

+ **Eligible for Employee Referral Bonus**

+ **Eligible for Relocation Benefit**

+ \#LI-PFE

**Sunshine Act**

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

**EEO & Employment Eligibility**

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development
Posted: 2020-10-13 Expires: 2020-11-13
Sponsored by:
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Postdoctoral Research Fellow

Andover, MA 01810

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