1+ months

Postdoc Translational Modeling and Simulation

Pfizer
Cambridge, MA 02139
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**ROLE SUMMARY**

The Pfizer BioMedicine Design group based in Cambridge, MA is seeking to recruit a postdoctoral researcher to undertake a project developing a quantitative systems pharmacology (QSP) model for predicting human efficacious dose of immuno-oncology (I-O) therapeutics. While immune therapy has changed the landscape of cancer treatments, patients' response to immune therapies vary. Capability to predict human efficacious doses at the preclinical research stage not only assists resource allocation but also informs clinical trial design. However, challenges remain in the preclinical to clinical translation, especially for I-O therapeutics. Quantitative systems pharmacology modeling is a mathematical approach to distill the interplay between a drug of interest, the immune system and the cancer cells. The postdoctoral candidate will work in the translational modeling and simulation group, and collaborate with biologists, clinical pharmacologists, pharmacometrians and clinicians to develop a QSP model for human efficacious dose prediction and to estimate the associated uncertainty via virtual patient simulations. The successful candidate will have exposure to preclinical and clinical research in the development of both large and small molecules. The desired outcome of the project is to inform human efficacious dose predictions at the stage of preclinical research for I-O therapeutics within Pfizer and beyond.



The appointment is initially two years, with an option for two annual extensions, based on research needs and progress, for a total maximum term of four years.



**ROLE RESPONSIBILITIES**



+ Identify literature and internal data to inform model development, optimization and validation

+ Employ modeling and simulation techniques to develop and subsequently validate a translational QSP model to predict human efficacious doses and the associated uncertainties of I-O drugs

+ Effectively communicate research to scientists with diverse backgrounds

+ Authorize scientific publications as the primary author and present at internal and external scientific meetings



**BASIC QUALIFICATIONS**



+ Recent Ph.D (0 - 3 years) in Engineering, Applied Mathematics, Physics, Pharmaceutical Sciences or related discipline with strong numerical components focusing on mathematical modeling and simulation

+ Previous experience in building QSP or ordinary differential equation-based models of biological or physiological systems

+ Computational fluency with modeling and simulation software (MATLAB, R, C/C++ preferred)

+ Primary authorship on relevant publications in peer-reviewed scientific journals

+ Self-directed, independent and motivated scientist who excels in a collaborative and multidisciplinary team environment

+ Must be willing to relocate to Cambridge, MA, USA

+ \#LI-PFE



**PREFERRED QUALIFICATIONS**



+ Knowledge in immunology, immuno-oncology or translational science

+ Excellent communication and writing skills

+ Creative and innovative early career scientist with a passion for learning new areas of biology and building on a solid foundation of quantitative and computational skills



**Sunshine Act**

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.



**EEO & Employment Eligibility**

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.



Research and Development
Posted: 2020-04-21 Expires: 2020-06-21
Sponsored by:
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Postdoc Translational Modeling and Simulation

Pfizer
Cambridge, MA 02139

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